1882 - 1966

In den 10er Jahren folgte ihre intensivste Zeit beim Film und sie verkörperte meist leidende Frauen in Filmen wie "For the Love of a Girl" (12), "The Last Rose of Summer" (12), "Friend John" (13), "Mary's Temptation" (13), "The Lion and the Mouse" (14), "The Gamblers" (14), "The Wolf" (14), "It All Depends" (15), "The Blessed Miracle" (15), "In the Dark" (15), "The Deception" (15), "A Woman's Way" (16), "Beyond the Wall" (16), "The Web of Desire" (17), "Easy Money" (17), "The Mystery Girl" (18), "The Woman Next Door" (19) und "A Sporting Chance" (19).

Ab den 20er Jahren wurde sie mehrheitlich für Nebenrollen engagiert, die ihrem schauspielerischen Vermögen nicht immer gerecht wurden.
Zu ihren bekanntesten Filmen dieser Jahre zählen "The Thirteenth Commandment" (20), "Young Mrs. Winthrop" (20), "The Sins of Rosanne" (20), "The Cradle" (22), "Wings of Youth" (25), "Risky Busines" (26) und "The Princess on Broadway" (27).

Im Tonfilm der 30er und 40er Jahre folgten nochmals unzählige Auftritte in Nebenrollen und sie agierte in populären Filmen wie "Call of the Circus" (30), "Thrill of Youth" (32), "The Crooked Circle" (32), "Private Jones" (33), "Easy to Take" (36), "Exclusive" (37), "Souls at Sea" (37), "Bulldog Drummond's Revenge" (37), "Wells Fargo" (37), "The Buccaneer" (38), "You and Me" (38), "If I Were King" (38), "Boy Trouble" (39), "Geronimo" (39), "New York Town" (41), "The Major and the Minor" (42), "True of Life" (43), "The Blue Dahlia" (46) und "The Perils of Pauline" (47).

Danach zog sich Ethel Clayton vom Filmgeschäft zurück.
Ethel Clayton war mit dem Schauspieler und Regisseur Joseph Kaufman und nach dessen Tod mit dem Schauspieler Ian Keith verheiratet.
 

Weitere Filme mit Ethel Clayton: 
The Tout's Remembrance (10) A Romance of the Coast (12) The Doctor's Debt (12) Just Maine Folk (12) The Wonderful One-Horse Shay (12) Home Sweet Home (12) His Code of Honor (13) When the Earth Trembled (13) Art and Honor (13) His Children (13) Heroes One and All (13) The Faith of a Girl (13) A Hero Among Men (13) Price Demanded (13) The New Gown (13) A Deal in Oil (13) When Tony Pawned Louisa (13) The Burning Rivet (13) The Doctor's Romance (13) The Daughters of Men (14) A Daughter of Eve (14) The House Next Door (14) The Fortune Hunter (14) The Stolen Yacht (14) The Furnace Man (15) The Attorney for the Defense (15) His Soul Mate (15) A Woman Went Forth (15) Margie Puts One Over (15) Here Comes the Bride (15) The Unmarried Husband (15) Capturing the Crook (15) Just Look at jake (15) The College Widow (15) The Darkness Before Dawn (15) The Sporting Duchess (15) When the Light Came In (15) The Earl's Adventure (15) A Day of Havoc (15) It Was to Be (15) In Spite of Him (15) The Great Divide (15) Dollars and the Woman (16) His Brother's Wife (16) Husband and Wife (16) The Hidden Scar (16) The New South (16) The Woman Beneath (17) Man's Woman (17) The Bondage of Fear (17) Yankee Pluck (17) The Stolen Paradise (17) Souls Adrift (17) The Dormant Power (17) Stolen Hours (18) The Whims of Society (18) The Witch Woman (18) Journey's End (18) The Man Hunt (18) The Girl who Came Back (18) A Soul Without Windows (18) Women's Weapons (18) Vicky Van (19) Maggie Pepper (19) Pettigrew's Girl (19)  Men, Women, and Money (19) More Deadly Than the Male (19) A Lady in Love (20) The Ladder of Lies (20) Crooked Streets (20) A City Sparrow (20) Exit the Vamp (21) The Price of Posssession (21) Sham (21) Wealth (21) Beyond (21) Her Own Money (22) For the Defense (22) If I Were Queen (22) Can a Woman Love Twice? (23) The Remittance Woman (23) The Mansion of Aching Hearts (25) Wings of Youth (25) Lightnin' (25) The Bar-C Mystery (26) Sunny Side Up (26) The Merry Widower (26) His New York Wife (26) The Princess from Hoboken (27) Mother Machree (28) Hit the Deck (30) Hotel Continental (32) The All-American (32) Secrets (33) The Whispering Shadow (33) Hollywood Boulevard (36) The Accusing Finger (36) Rich Relations (37) King of Gamblers (37) Make Way for Tomorrow (37) Turn Off the Moon (37) Easy Living (37) Artists & Models (37) Blonde Trouble (37) Partners in Crime (37) Hold 'Em Navy (37) Scandal Street (38) The Big Broadcast of 1938 (38) Bulldog Drummond's Peril (38) Cocoanut Grove (38) Men with Wings (38) Sing You Sinners (38) The Arkansas Traveler (38) Say It in French (38) Ride a Crooked Mile (38) Artists and Models Abroad (38) Tom Sawyer, Detective (38) Ambush (39) Paris Honeymoon (39) St. Louis Blues (39) Café Society (39) The Sap Takes a Wrap (39) King of Chinatown (39) I'm from Missouri (39) Grand Jury Secrets (39) West Point Widow (41) Beyond the Blue Horizon (42) Lucky Jordan (42) Lady Bodyguard (43) Dixie (43) Mardi Gras (43) Henry Aldrich's Little Secret (44)